Profile
Education and Training
Post-Doctoral Training Department of Psychiatry & Behavioral Neuroscience, The University of Chicago, 2007.11-2010.08
B.S.    East China Normal University (ECNU), Biochemistry, 1998-2002.
Ph.D.  Fudan University, Genetics, 2002-2007.

 

Selected Publications

1.Zhang D#, Li Z#, Xu X, Zhou D, Tang S, Yin X, Xu F, Li H, Zhou Y, Zhu T, Deng H, Zhang S, Huang Q, Wang J, Yin W, Zhu Y, Lai M.Deletions at SLC18A1 increased the risk of CRC and lower SLC18A1 expression associated with poor CRC outcome.Carcinogenesis. 2017 Oct 26;38(11):1057-1062. doi: 10.1093/carcin/bgx088. (co-first author and co-corresponding author)

2.Zhu Y#, Zhang D#, Zhou D#, Li Z#, Li Z, Fang L, Yang M, Shan Z, Li H, Chen J, Zhou X, Ye W, Yu S, Li H, Cai L, Liu C, Zhang J, Wang L, Lai Y, Ruan L, Sun Z, Zhang S, Wang H, Liu Y, Xu Y, Ling J, Xu C, Zhang Y, Lv D, Yuan Z, Zhang J, Zhang Y, Shi Y, Lai M.Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.J Cell Mol Med. 2017 Jun;21(6):1106-1116. doi: 10.1111/jcmm.13042. Epub 2017 Mar 30.(co-first author)

3.Zhou D#, Zhang D#, Sun X#, Li Z#, Ni Y, Shan Z, Li H, Liu C, Zhang S2, Liu Y, Zheng R, Pan F, Zhu Y, Shi Y, Lai M.A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study. Eur J Hum Genet. 2018 Feb 23. doi: 10.1038/s41431-018-0108-4. [Epub ahead of print] (#co-first author)

4.Zhang D, Yang M, Zhou D, Li Z, Cai L, Bao Y, Li H, Shan Z, Liu J, Lv D, Liu Y, Xu C, Ling J, Xu Y, Zhang S, Huang Q, Shi Y, Zhu Y, Lai M.The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study.Gene. 2018 Apr 20;651:62-69. doi: 10.1016/j.gene.2018.01.064. Epub 2018 Feb 7.

 

5. Dan Zhou, Zhenli Li, Dan Yu, Ledong Wan, Yimin Zhu, Maode Lai*, Dandan Zhang*. Polymorphismsinvolving gain or loss of CpG sites are significantly enriched in trait-associated SNPs. Oncotarget (accepted) 2015. * co-corresponding author

 

6.Zhenli Li , Dan Yu, MeifuGan, Qiaonan Shan, Xiaoyang Yin, Shunli Tang, Shuai Zhang, Yongyong Shi, Yimin Zhu, Maode Lai*, Dandan Zhang*,  A Genome-wide Assessment of Rare Copy Number Variants in Colorectal Cancer. Oncotarget. 2015 Jul 20. [Epub ahead of print] * co-corresponding author

7.Yu D, Li Z, Gan M, Zhang H, Yin X, Tang S, Wan L, Tian Y, Zhang S, Zhu Y, Lai M, Zhang D*. Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients. Tumour Biol. 2015 [Epub ahead of print]   *corresponding author

 

8.Zhang D#, Li Z#, Wang H, Yang M, Liang L, Fu J, Wang C, Ling J, Zhang Y, Zhang S, Xu Y, Zhu Y, Lai M. Interactions between obesity-related copy number variants and dietary behaviors in childhood obesity. Nutrients 2015, 7(4), 3054-3066. #co-first author

 

9. Duo Lv#, Dan-Dan Zhang#, Hao Wang, Yan Zhang, Li Liang, Jun-Fen Fu, Feng Xiong, Ge-Li Liu, Chun-Xiu Gong, Fei-Hong Luo, Shao-Ke Chen, Zhen-Li Li, Yi-Min Zhu. Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population.Gene2015560149-155.#co-first author

 

10. Dandan Zhang, Yudong Qian, Nirmala Akula, Ney Alliey-Rodriguez, Jinsong Tang, Elliot S Gershon, Chunyu Liu. Accuracy of CNV Detection from GWAS Data. PLos One, 2011,6(1): e14511-e1451

 

11. Dandan Zhang*, Lijun Cheng*, Judith A Badner, Chao Chen, Qi Chen, Wei Luo, Margot Redman, David W Craig, Elliot S Gershon, Chunyu Liu. Genetic control of individual differences in gene-specific methylation in human. Am J Hum Genet. 2010, 86(3):411-9 (*equal contribution authors)

 

12. Dandan Zhang, Lijun Cheng, David W Craig, Margot Redman, Chunyu Liu. Cerebellar telomere length and psychiatric disorders. Behav Genet. 2010 40(2):250-4.

 

13. Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey-Rodriguez, et al. Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder. Mol Psychiatry. 2009 14(4):376-80.

 

14. Dandan Zhang, Chunhong Shao, Minhua Shao, Pengrong Yan, Yi Wang, Yixiao Liu, Wenhong Liu, Tong Lin, Yuying Xie , Yingnan Zhao, Daru LuYifeng Li and Li Jin. Effect of μ-opioid Receptor Gene Polymorphisms on Heroin-induced Subjective Responses in a Chinese Population. Biol Psychiatry. 2007 61(11):1244-51.

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Research work

1)Copy number variation: Discovering the roles of copy number variations in complex diseases. 2) Genetics of complex diseases: Hunting for causal and susceptible genes underlining complex diseases by population-based and family-based strategies; identification of the functional effect of the genetic variants interested using molecular biology methods and animal models. 3) Epigenetics of complex diseases: Identification of DNA methylation changes in complex disease and dynamic DNA methylation changes over time. 4) Pharmacogeomics: To study how an individual's genetic inheritance affects the individual body's response to drugs, and further invention of more powerful medicines or new administration method, which will provide theoretic foundation to the individual therapy.

Contact

Phone:0571-88208138
E-mail:dandanz@zju.edu.cn