Profile

Prof. Fang graduated from Zhejiang Medical University in 1989, 1994, &2005. He visited the Chinese University of Hong Kong during 2003- 2005, received his Ph. D. from Zhejiang University in 2005. He worked as a postdoctoral fellowship at the Chinese University of Hong Kong & University of Hong Kong during 2005-2008. In 1996-97 he studied at Medical University of Luebeck in Germany as a visiting scholar. He serves as a reviewer for several international journals including “Toxicology letters”, “Microscopy Research and Technique”, “the Anatomical Record”, and “International Journal of Cell Biology”
In particular, he is interested in elucidating the role of miRNAs in neurobiology, and also,the role of 5-HT and its receptors along brain-gut axis in IBS models with visceral hypersensitivity mechanisms.
Publications;

1).Fang M, Sun Y, Hu Z, Yang J, Davies H, Wang B, Ling S, Han S. C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. Neuropharmacology. 2013 Jul;70:83-99.
2). Fang M, Yin Y, Chen H, Hu Z, Davies H, Ling S. Contribution of Rag1 to spatial memory ability in rats. Behav Brain Res. 2013 Jan 1;236(1):200-9.
3). Hu X, Li Y, Hu Z, Rudd JA, Ling S, Jiang F, Davies H, Fang M. The alteration of 5-HT(2A) and 5-HT(2C) receptors is involved in neuronal apoptosis of goldfish cerebellum following traumatic experience. Neurochem Int. 2012 Jul;61(2):207-18.
4).Fang M., Huang J., Ling SC., Rudd JA., Yew DT., Han S. Effects of Reg-2 on survival of spinal cord neurons in vitro. Anat Rec., 2010, 293(3):464-476.
5).Hu Z., Li Y., Fang M., Wai MS., Yew DT.Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration.Curr Med Chem. 2009, 16(11):1418-1425.
6).Fang M., Hu Z., Li Y., Li J., Yew DT., Ling S. Nestin positive cells in the retina and spinal cord of the sturgeon after hypoxia. Int J Neurosci., 2009, 119(4):460-470.
7) .Lü L., Mak YT., Fang M., Yew DT. The difference in gliosis induced by beta-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains. Biogerontology. 2009 Feb 17.
8). Xia H., Qi Y, Ng SS., Chen X., Chen S., Fang M., Li D., Zhao Y., Ge R., Li G., Chen Y., He ML., Kung HF., Lai L., Lin MC. MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem Biophys Res Commun., 2009 Jan 9.
9).Fang M., Li J., Tiu SC., Zhang L., Wang M., Yew DT. N-methyl-D-aspartate receptor and apoptosis in Alzheimer's disease and multiinfarct dementia. J Neurosci Res., 2005, 81(2):269-274.
10).Fang M., Li J., Gong X., Lu G., Kwong WH., Wai SM., Yew DT.A fMRI study of age-related differential cortical patterns during cued motor movement. Brain Topogr.,2005, 17(3):127-137.
11).Fang M., Li J., Rudd JA., Wai SM., Yew JC., Yew DT. fMRI Mapping of cortical centers following visual stimulation in postnatal pigs of different ages. Life Sci., 2006, 78(11):1197-201.
12).Fang M., Li J., Gong X., Kwong WH., Lu G., Wai SM., Yew DT. Myenilation of the pig's brain: a correlated MRI and histological study. Neurosignals., 2005;14(3):102-108.
13).Fang M., Zhang L., Li J., Wang C., Chung CH., Wai SM., Yew DT. The postnatal development of the cerebellum- a FMRI and silver study. Cell Mol Neurobiol., 2005, 25(6):1043-1050.
14).Fang M., Lorke DE., Li J., Gong X., Yew JC., Yew DT. Postnatal changes in functional activities of the pig's brain: a combined functional magnetic resonance imaging and immunohistochemical study. Neurosignals., 2005,14(5):222-233.
15).Fang M., Li J., Kwong WH., Kindler P., Lu G., Wai SM., Yew DT. The complexity of the visual cells and visual pathways of the sturgeon. Microsc Res Tech. 2004;65(3):122-129.
16).Fang M., Li J., Wai SM., Yew DT. Twin cones or double cones in fish-a misnomer or different morphological forms. Int J Neurosci., 2005, 115(7):981-987.
17).Gong X., Fang M., Wang J., Sun J., Zhang X., Kwong WH., Yew DT. Three-dimensional reconstruction of brain surface anatomy based on magnetic resonance imaging diffusion-weighted imaging: a new approach. J Biomed Sci., 2004, 11(6):711-6.
18).Lee FK., Fang M., Antonio GE., Yeung DK., Chan ET., Zhang LH., Yew DT., Ahuja AT. Diffusion Tensor Imaging (DTI) of in-vivo rodent brains with a 1.5T clinical MR-scanner. J Magn Reson Imaging., 2006, 23(5):747-751.
19).Lu G., Mak YT., Wai SM., Kwong WH., Fang M., James A., Randall D., Yew DT. Hypoxia-induced differential apoptosis in the central nervous system of the sturgeon (Acipenser shrenckii).Microsc Res Tech., 2005, 68(5):258-263.
20).Liang Y., Fang M., Li J., Yew DT. Immunohistochemical localization of endothelial isoform (eNOS) in human cerebral arteries and the aorta.Int J Neurosci., 2006, 116(12):1403-1417.
21).Liang Y., Fang M., Li J., Liu CB., Rudd JA., Kung HF., Yew DT. Serum proteomic patterns for gastric lesions as revealed by SELDI mass spectrometry. Exp Mol Pathol., 2006, 81(2):176-180.
22).Liang Y., Fang M., Li J., Wai MS., Lam WP., Yew DT. Vagus, hypoglossal, and median nerves in human development. Int J Neurosci., 2007, 117(4):453-464.
23).Lü LH., Li JC., Wai MS., Lam WP., Forster EL., Fang MR.,Yew DT. Perinatal hypoxia induces subsequent retinal degeneration in the offspring of ovoviviparous fish, Xiphophorous maculates. Vet Ophthalmol., 2007, 10(5):289-294.

Research work

In particular, he is interested in elucidating the role of miRNAs in neurobiology of disease, and also,the role of 5-HT and its receptors along brain-gut axis in IBS models with visceral hypersensitivity mechanisms. Main approaches used: Primary cultured neurons, or PC12 & SK-N-SH cell lines; In Situ hybridization with fluorescent LNAs probes; Synapse immunolabeling, morphological studies using confocal microscopy and electron microscopy, immuno- histochemistry and electron microscopy; Real-time PCR detection of matured miRNAs; Western blotting f, gene transfection using miRNAs mimics or inhibitors.

Contact

Phone:88208160
E-mail:fangmaro@163.com