Profile

Education

1. 09/1995-04/1998: Beijing Medical University, China, PhD.

2. 09/1987-08/1990: Jiangxi University of Traditional Chinese Medicine, China, MS.

3. 09/1980-07/1984: Jiangxi University of Traditional Chinese Medicine, China, BS.

Employment

1. 11/2011- present: Professor, Ocean College, Zhejiang University, China.

2. 11/2008-11/2011:  Senior Scientist, NovoBiotic Pharmaceuticals, USA.

3. 01/2002-10/2008: Research Scientist, National Center for Pharmaceutical Crops, SFA State University, USA.

4. 08/1999-12/2001: Postdoctoral Research Associate, National Center for Natural Products Research, the University of Mississippi, USA.

5. 05/1998-06/1999: Visiting Research Scholar, Toho University, Japan.

6. 09/1990-08/1995: Associate Professor, Jiangxi University of Traditional Chinese Medicine, China.

7. 08/1984-08/1987: Assistant Teacher, Jiangxi University of Traditional Chinese Medicine, China.

Awards and Honors

1. Science and Technology Advancement Third Prize of Jiangxi Province.

2. National Chinese Medicinal Science and Technology Advancement Second Prize.

3. National Chinese Medicinal Science and Technology Advancement Third Prize.

Research Support

1. Discovery and bioactive study of novel anti-glioma lead compounds from marine microorganisms based on the strategy by manipulating multiple targets of tumor metabolism, the National Natural Science Foundation of China.

2. Discovery of novel antibiotics from marine bacteria cultured in simulated native environment, the National Natural Science Foundation of China.

3. Study of the anti-glioma effect and mechanism of sulfated saponins from sea cucumber Holothuria moebii Ludwig based on tumor metabolism, the Zhejiang Province Natural Science Foundation.

4. Preclinical study of novel anti-glioma drug candidate tripolinolate A, the Science Technology Department of Zhejiang Province.

5. Discovery of novel antibiotics from marine microorganisms cultured by new methods, the Cross-Disciplinary Research for Ocean Science of Zhejiang University.

Representative Publications (over 96 publications)

Chen MX, Chai WY, Song TF, Ma MZ, Lian XY*, Zhang ZZ*. 2018. Anti-glioma natural products downregulating tumor glycolytic enzymes from marine actinomycete Streptomyces sp. ZZ406. Scientific Reports, 8(1): 72.

Li Q, Zhu RY, Yi WW, Chai WY, Zhang ZZ*, Lian XY*. 2018. Feniciphenalenins A-F from the culture of a marine-associated fungus Penicillium sp. ZZ901. Phytochemistry, 152: 53-60.

Song TF, Chen MX, Chai WY, Zhang ZZ*, Lian XY*. 2018. New bioactive pyrrospirones C-I from a marine-derived fungus Penicillium sp. ZZ380 Tetrahedron, 74: 884-891.

Chen MX, Chai WY, Zhu RY, Song TF, Zhang ZZ*, Lian XY*. 2018. Streptopyrazinones A-D, rare metabolites from marine-derived Streptomyces sp. ZZ446. 

Chai WY, Chen L, Lian XY*, Zhang ZZ*. 2018. Anti-glioma efficacy and mechanism of action of Tripolinolate A from Tripolium pannonicum. Planta Medica, available online 25 January.

Anjum K, Bi HY, Chai WY, Lian XY*, Zhang ZZ*. 2018. Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumor metabolic enzymes. Natural Products Research, 32(11): 1353-1356.

Wang WL, Song TF, Chai WY, Chen L, Chen L, Lian XY*, Zhang ZZ*. 2017. Rare polyene-polyol macrolides from mangrove-derived Streptomyces sp. ZQ4BG. Scientific Reports, 7(1): 1703.

Chen L, Chai WY, Wang WL, Song TF, Lian XY*, Zhang ZZ*. 2017. Anti-glioma bagremycins from mangrove-derived Streptomyces sp. Q22. Journal of Natural Products, 80: 1450-1456.

Zhang XF, Chen L, Chai WY, Lian XY*, Zhang ZZ*. 2017. A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E. Phytochemistry, 144: 119-126.

Ye XW, Anjum K, Song TF, Wang WL, Liang Y, Chen MX, Huang HC, Lian XY*, Zhang ZZ*. 2017. Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis. Phytochemistry, 135: 151-159.

Zhang ZZ*, Chen L, Zhang XF, Liang Y, Anjum K, Chen L, Lian XY*. 2017. Bioactive bafilomycins and a new N-arylpyrazinone derivative from marine-derived Streptomyces sp. HZP-2216E. Planta Medica, 83: 1405-1411.

Ye XW, Chai WY, Lian XY*, Zhang ZZ*. 2017. Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24. Natural Products Research, 31: 1390-1396.

Liang Y, Chen L, Ye XW, Anjum K, Lian XY*, Zhang ZZ*. 2017. New streptophenazines from marine Streptomyces sp. 182SMLY. Natural Product Research, 31: 411-417.

Chen L, Wang WL, Song TF, Ye XW, Liang Y, Huang HC, Yan SL, Lian XY*, Zhang ZZ*. 2017. Anti-colorectal tumor effects of tripolinolate A from Tripolium vulgareChinese Journal of Natural Medicines, 15: 576-583.

Zhang XF, Ye XW, Chai WY, Lian XY*, Zhang ZZ*. 2016. New metabolites and bioactive actinomycins from marine-derived Streptomyces sp. ZZ338. Marine Drugs, 14(10):181.

Liang Y, Xie X, Chen L, Yan SL, Ye XW, Anjum K, Huang HC, Lian XY*, Zhang ZZ*. 2016. Bioactive polycyclic quinones from marine Streptomyces sp. 182SMLY. Marine Drugs, 14(1): 10.

Ye XW, Anjum K, Song TF, Wang WL, Yu SR, Huang HC, Lian XY*, Zhang ZZ*. 2016. A new curvularin glycoside and its cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7. Natural Products Research30(10): 1156-1161.

Yu SR, Ye XW, Chen L, Xie X, Zhou Q, Lian XY*, Zhang ZZ*. 2015. Cytotoxic and anti-colorectal tumor effects of sulfated saponins from sea cucumber Holothuria moebiiPhytomedicine, 22(12): 1112-1119.

Chen L, Liang Y, Song TF, Anjum K, Wang WL, Yu SR, Huang HC, Lian XY*, Zhang ZZ*. 2015. Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogues. Bioorganic & Medicinal Chemistry Letters, 25(13): 2629-2633.

Yu SR, Ye XW, Huang HC, Peng R, Su ZH, Lian XY*, Zhang ZZ*. 2015. Bioactive sulfated saponins from sea cucumber Holothuria moebiiPlanta Medica, 81(2): 152-159.

Ye XW, Yu SR, Liang Y, Huang HC, Lian XY*, Zhang ZZ*. 2014. Bioactive triterpenoid saponins and phenolic compounds against glioma cells. Bioorganic & Medicinal Chemistry Letters, 24: 5157-5163.

Yu SR, Ye XW, Chen L, Lian XY*, Zhang ZZ*. 2014. Polyoxygenated 24,28-epoxyergosterols inhibiting the proliferation of glioma cells from sea anemone Anthopleura midoriSteroids, 88: 19-25.

Xu KN, Zhang YF, Wang Y, Ling P, Xie X, Jiang CY, Lian XY*, Zhang ZZ*. 2014. Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration. PloS One, 9(6): e101077.

Yu SR, Ye XW, Xin WX, Xu KN, Lian XY*, Zhang ZZ*. 2014. Fatsioside A, a rare baccharane-type glycoside inhibiting the growth of glioma cells from the fruits of Fatsia japonicaPlanta Medica, 80: 315-320.

Ye XW, Yu SR, Lian XY*, Zhang ZZ*. 2014. Quantitative determination of triterpenoid glycosides in Fatsia japonica Decne. & Planch. using high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 88, 472-476.

Xin WX, Zhang YH, Xie X, Tong YH, Zhang ZZ*, Lian XY*. 2013. Caffeic acid 3,4-dihydroxyphenethyl ester arrests colorectal cancer cells growth by upregulating phosphorylation of p38 MAPK. Acta Pharmacol Sinica, S34: 16.

Lian XYZhang ZZ*. 2013. Indanomycin-related antibiotics from marine Streptomyces antibioticus PTZ0016. Natural Product Research, 27(23): 2161-2167.

Guo X, Shen L, Tong YH, Zhang J, Wu G, He Q, Yu SR, Ye XW, Zou L, Zhang ZZ*, Lian XY*. 2013. Antitumor activity of caffeic acid 3,4-dihydroxy phenethyl ester and its pharmacokinetic and metabolic properties. Phytomedicine, 20: 904-912.

Lian XY, Zhang ZZ*. 2013. Quantitive analysis of gleditsia saponins in Gleditsia sinensis Lam by high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 75: 41-46.

Xin WX, Ye XW, Yu SR, Lian XY*, Zhang ZZ*. 2012. New apoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025. Marine Drugs, 10: 2388-2402.

Zhang ZZ, Xiao BH, Chen Q, Lian XY*. 2010. Synthesis and biological evaluation of caffeic acid 3,4-dihydroxyphenethyl ester. Journal of Natural Products, 73: 252-254.

Zhang ZZ, Wang P, Yuan W, Li SY*. 2008. Steroids, alkaloids, and coumarins from Gelsemium sempervirens.  Planta Medica, 74: 1818-1822.

Zhang ZZ, Li SY*, Ownby S, Wang P, Yuan W, Zhang WL, Beasley SR. 2008. Phenolic compounds and rare polyhydroxylated triterpenoid saponins from Eryngium yuccifolium. Phytochemistry, 69: 2070-2080.

Zhang ZZ, Li SY*. 2007. Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L. Phytochemistry, 68: 2075-2086.

Zhang ZZ, Li SY*, Zhang SM, Gorenstein D. 2006. Triterpenoid saponins from the fruits of Aesculus paviaPhytochemistry, 67: 784-794.

Lian XY, Zhang ZZ, Stringer JL*. 2006. Anticonvulsant and neuroprotective effects of ginsenosides in rats. Epilepsy Research, 70: 244-256.

Zhang ZZ, Li SY*, Zhang SM. 2005. Six new triterpenoid saponins from the root and stem bark of Cephalanthus occidentalisPlanta Medica, 71: 355-361.

Lian XY, Zhang ZZ, Stringer JL*. 2005. Protective effects of ginseng components in a rodent model of neurodegeneration. Annals of Neurology, 57: 642-648.

Lian XY, Zhang ZZ, Stringer JL*. 2005. Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. Epilepsia, 46: 15-22.

Zhang ZZ, Li SY*, Zhang SM, Liang C, Gorenstein D, Beasley SR. 2004. New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminataPlanta Medica, 70: 1216-1221.

Zhang ZZ, ElSohly HN*, Li XC, Khan SI, Broedel Jr. SE, Raulli RE, Cihlar RL, Walker LA*. 2003. Phenolic compounds from Nymphaea odorataJournal of Natural Products, 66: 548-550.

Zhang ZZ, ElSohly HN*, Li XC, Khan SI, Broedel Jr. SE, Raulli RE, Cihlar RL, Walker LA*. 2003. Flavanone glycosides from Miconia trailiiJournal of Natural Products, 66: 39-41.

Zhang ZZ, ElSohly HN*, Jacob MR, Pasco DS, Walker LA, Clark AM*. 2002. Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuumJournal of Natural Products, 65: 979-985.

Zhang ZZ, ElSohly HN*, Melissa R. Jacob, David S. Pasco, Larry A. Walker, Alice M. Clark*. 2002. New sesquiterpenoids from the root of Guatteria multivenia.  Journal of Natural Products, 65: 856-859.

Zhang ZZ, ElSohly HN*, Jacob MR, Pasco DS, Walker LA, Clark AM*. 2002. Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.  Planta Medica, 68: 49-54.

Zhang ZZ, ElSohly HN*, Jacob MR, Pasco DS, Walker LA, Clark AM*. 2001. New indole alkaloids from the bark of Nauclea orientalis.  Journal of Natural Products, 64: 1001-1005.

Zhang ZZ, Guo DA, Zheng JH*, Koike K, Jia ZH, Nikaido T. 1999. Gaulthrins C and D, two new lignans from the roots of Gaultheria yunnanensisHeterocycles, 53: 675-679.

Zhang ZZ, Koike K, Jia ZH, Nikaido T*, Guo DA, Zheng JH. 1999. New saponins from the seeds of Aesculus chinensisChemical & Pharmaceutical Bulletin, 47: 1515-1520.

Zhang ZZ, Guo DA, Li CL, Zheng JH*, Koike K, Jia ZH, Nikaido T. 1999. Gaultherins A and B, two lignans from Gaultheria yunnanensisPhytochemistry, 51: 469-472.

Zhang ZZ, Koike K, Jia ZH, Nikaido T*, Guo DA, Zheng JH. 1999. Triterpenoidal saponins from Gleditsia sinensisPhytochemistry, 52: 715-722.

Zhang ZZ, Koike K, Jia ZH, Nikaido T*, Guo DA, Zheng JH. 1999. Gleditsiosides N-Q, new triterpenoid saponins from Gleditsia sinensisJournal of Natural Products, 62: 877-881.

Zhang ZZ, Koike K, Jia ZH, Nikaido T*, Guo DA, Zheng JH. 1999. Four new triterpenoidal saponins acylated with one monoterpenic acid from Gleditsia sinensisJournal of Natural Products, 62: 740-745.

Zhang ZZ, Koike K, Jia ZH, Nikaido T*, Guo DA, Zheng JH. 1999. Triterpenoidal saponins acylated with two monoterpenic acids from Gleditsia sinensis. Chemical & Pharmaceutical Bulletin, 47: 388-393.

Zhang ZZ, Guo DA, Li CL, Zheng JH*, Koike K, Jia ZH, Nikaido T. 1999. Two diterpenoids from the roots of Gaultheria yunnanensis. Journal of Natural Products, 62: 297-298


Research work

1. Discovery of novel bioactive compounds from the secondary metabolites of marine organisms. 2. Investigation and utilization of new marine medicinal resources. 3. Culture and purification of marine microorganism. 4. Structure modification and semi-synthesis of novel marine bioactive compounds. 5. Discovery and development of new pharmaceuticals, functional foods, and agrochemicals.

Contact

Phone:+86 13675859706
E-mail:zzhang88@zju.edu.cn