Profile
 
Education
1.         Ph.D. – Beijing Medical University, China, 1995-1998.
2.         M. S. – Jiangxi University of Traditional Chinese Medicine, China, 1987-1990.
3.         B. S. – Jiangxi University of Traditional Chinese Medicine, China, 1980-1984.
 
Employment
1.         11/2011 - present   Professor, Ocean College, Zhejiang University, China. 
2.         11/2008-11/2011   Senior Scientist, NovoBiotic Pharmaceuticals, USA.
3.         01/2002-10/2008   Research Scientist, National Center for Pharmaceutical Crops, SFA State University, USA.
4.         08/1999-12/2001   Postdoctoral Research Associate, National Center for Natural Products Research, the University of Mississippi, USA.
5.         05/1998-06/1999   Visiting Research Scholar, Toho University, Japan.
6.         09/1990-08/1995   Associate Professor, Jiangxi University of Traditional Chinese Medicine, China.
7.         08/1984-08/1987   Assistant Teacher, Jiangxi University of Traditional Chinese Medicine, China.
 
Awards and Honors
1.         Science and Technology Advancement Third Prize of Jiangxi Province, 1997.
2.         National Chinese Medicinal Science and Technology Advancement Second Prize, 1996.
3.         National Chinese Medicinal Science and Technology Advancement Third Prize, 1994.
 
Current Research Support
1.       Discovery of novel antibiotics from marine bacteria cultured in simulated native environment, the Natural Science Foundation of China, 2013-2016.
2.       Discovery of novel antibiotics from marine microorganisms cultured by new methods, the Cross-Disciplinary Research for Ocean Science of Zhejiang University, 2011-2013.
 
Representative Publications (over 80 publications)
    • Siran Yu, Xuewei Ye, Lu Chen, Xin Xie, Qian Zhou, Xiao-Yuan Lian, Zhizhen Zhanga,*(2015). Cytotoxic and anti-colorectal tumor effects of sulfated saponins from sea cucumber Holothuria moebii. Phytomedicine, accepted.
  • Lu Chen, Ying Liang, Tengfei Song, Komal Anjum, Wenling Wang, Siran Yu, Haocai Huang, Xiao-Yuan Lian*, Zhizhen Zhang* (2015). Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs. Bioorganic & Medicinal Chemistry Letters, 25(13), 2629-2633.
    • Xuewei Ye, Komal Anjum, Tengfei Song, Wenling Wang, Siran Yu, Haocai Huang, Xiao-Yuan Lian*, Zhizhen Zhang* (2015). A new curvularin glycoside and cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7. Natural Product Research, June 29, 1-6.
       
  • Siran Yu, Xuewei Ye, Haocai Huang, Rui Peng, Zenghua Su, Xiao-Yuan Lian*, Zhizhen Zhang* (2015). Bioactive sulfated saponins from sea cucumber Holothuria moebii. Planta Medica, 81(2):152-159.
  • Xuewei Ye, Siran Yu, Ying Liang, Haocai Huang, Xiao-Yuan Lian*, Zhizhen Zhang* (2014). Bioactive triterpenoid saponins and phenolic compounds against glioma cells. Bioorganic & Medicinal Chemistry Letters, 25:5157-5163.
  • Siran Yu, Xuewei Ye, Lu Chen, Xiao-Yuan Lian*, Zhizhen Zhang* (2014). Polyoxygenated 24,28-epoxyergosterols inhibiting the proliferation of glioma cells from sea anemone Anthopleura midori. Steriods, 88:19-25.
  • Kangning Xu, Yufen Zhang, Yan Wang, Peng Ling, Xin Xie, Chenyao Jiang, Zhizhen Zhang*, Xiao-Yuan Lian* (2014). Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration. PloS One, 9(6):e101077.
  • Siran Yu, Xuewei Ye, Wenxiu Xin, Kangning Xu, Xiao-Yuan Lian*, Zhizhen Zhang* (2014). Fatsioside A, a Rare Baccharane-Type Glycoside Inhibiting the Growth of Glioma Cells from the Fruits of Fatsia japonica. Planta Medica, 80:315-320.
  • Xuewei Ye, Siran Yu, Xiao-Yuan Lian, Zhizhen Zhang* (2014). Quantitative determination of triterpenoid glycosides in Fatsia japonica Decne. & Planch. using high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 88:472-476.
  • Xin Guo, Lu Shen, Yuhua Tong, Jian Zhang, Gang Wu, Qiong He, Siran Yu, Xuewei Ye, Libo Zou, Zhizhen Zhang*, Xiao-Yuan Lian* (2013). Antitumor activity of caffeic acid 3, 4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties. Phytomedicine, 20:904-912.
  • Xiao-Yuan, Zhizhen Zhang* (2013). Indanomycin-related antibiotics from marine Streptomyces antibioticus PTZ0016. Natural product Research, 27:2161-2167.
  • Xiao-Yuan Lian, Zhizhen Zhang* (2013). Quantitive analysis of gleditsia saponins in Gleditsia sinensis Lam by high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 75:41-46.
  • Wenxiu Xin, Xuewei Ye, Siran Yu, Xiao-Yuan Lian*, Zhizhen Zhang* (2012). New apoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025. Marine Drugs, 10:2388-2402.
  • Zhizhen Zhang, Wei Yuan, Ping Wang, Greg Grant, Shiyou Li (2011). Flavonoids from Lupinus texensis and their free radical scavenging activity. Natural Product Research, 25:1641-1649.
  • Zhizhen Zhang, Stacy Ownby, Ping Wang, Wei Yuan, Wanli Zhang, Shiyou Li (2010). New phenolic compounds from Liatris elegans. Natural Product Research, 24:1079-1085.
  • Zhizhen Zhang, Binghua Xiao, Qi Chen, Xiao-Yuan Lian (2010). Synthesis and biological evaluation of caffeic acid 3,4-dihydroxyphenethyl ester. Journal of Natural Products, 73:252-254.
  • Zhizhen Zhang*, Shiyou Li, Xiao-Yuan Lian (2010). An overview of the genus Aesculus L.: ethnobotany, phytochemistry, and pharmacological activities. Pharmaceutical Crops, 1:24-51.
  • Zhizhen Zhang*, Xiao-Yuan Lian, Shiyou Li, Janet L. Stringer (2009). Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora). Phytomedicine, 16:485-493.
  • Zhizhen Zhang, Ping Wang, Wei Yuan, Shiyou Li (2008). Steroids, alkaloids, and coumarins from Gelsemium sempervirens. Planta Medica, 74:1818-1822.
  • Zhizhen Zhang, Shiyou Li, Stacy Ownby, Ping Wang, Wei Yuan, Wanli Zhang, Scott R. Beasley (2008). Phenolic compounds and rare polyhydroxylated triterpenoid saponins from Eryngium yuccifolium. Phytochemistry, 69:2070-2080.
  • Zhizhen Zhang, Shiyou Li (2007). Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L. Phytochemistry, 68:2075-2086.
  • Zhizhen Zhang, Shiyou Li, Shangming Zhang, David Gorenstein (2006). Triterpenoid saponins from the fruits of Aesculus pavia. Phytochemistry, 67:784- 794.
  • Zhizhen Zhang, Shiyou Li, Shangming Zhang (2005). Six new triterpenoid saponins from the root and stembark of Cephalanthus occidentalis. Planta Medica, 71:355-361.
  • Xiao-Yuan Lian, Zhizhen Zhang, Janet L. Stringer (2005). Protective effects of ginseng components in a rodent model of neurodegeneration. Annals of Neurology, 57:642-648.
  • Xiao-yuan Lian, Zhizhen Zhang, Janet L. Stringer (2005). Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. Epilepsia, 46: 15-22.
  • Zhizhen Zhang, Shiyou Li, Shanmin Zhang, Chun Liang, David Gorenstein, Scott R. Beasley (2004). New camptothecin and ellagic acid analogues from the root barks of Camptotheca acuminata. Planta Medica, 70:1216-1221.
  • Zhizhen Zhang, Hala N. ElSohly, Xing-Cong Li, Shabana I. Khan, Sheldon E. Broedel Jr., Robert E. Raulli, Ronald L. Cihlar, Larry A. Walker (2003). Phenolic compounds from Nymphaea odorata. Journal of Natural Products, 66: 548-550. Zhizhen Zhang, Hala N. ElSohly, Xing-Cong Li, Shabana I. Khan, Sheldon E. Broedel Jr., Robert E. Raulli, Ronald L. Cihlar, Larry A. Walker (2003). Flavanone glycosides from Miconia trailii. Journal of Natural Products, 66: 39-41.
  • Zhizhen Zhang, Hala N. ElSohly, Melissa R. Jacob, David S. Pasco, Larry A. Walker, Alice M. Clark (2002). New sesquiterpenes from the root of Gautteria multiveria. Journal of Natural Products, 65: 856-859.
  • Zhizhen Zhang, Hala N. ElSohly, Melissa R. Jacob, David S. Pasco, Larry A. Walker, Alice M. Clark (2002). Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum. Journal of Natural Products, 65: 979-985.
  • Zhizhen Zhang, Hala N. ElSohly, Melissa R. Jacob, David S. Pasco, Larry A. Walker, Alice M. Clark (2002). Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta medica, 68: 49-54.
  • Zhizhen Zhang, Hala N. ElSohly, Melissa R. Jacob, David S. Pasco, Larry A. Walker, Alice M. Clark (2001). Novel indole alkaloids from the bark of Nauclea orientalis. Journal of Natural Products, 64: 1001-1005.
  • Zhizhen Zhang, Dean Guo, Junhua Zheng, Kazuo Koike, Zhonghua Jia, Tamotsu Nikaido (2000). Gaulthrins C and D, two new lignans from the roots of Gaultheria yunnanensis. Heterocycles, 53: 675-679.

 

Research work

1.Discovery of novel bioactive compounds from the secondary metabolites of marine organisms. 2.Investigation and utilization of new marine medicinal resources. 3.Culture and purification of marine microorganism. 4.Structure modification and semi-synthesis of novel marine bioactive compounds. 5.Discovery and development of new pharmaceutical, dietary and agrochemical products based on on the marine bioactive compounds.

Contact

Phone:+86 13675859706
E-mail:zzhang88@zju.edu.cn