个人简介
于洪巍   博士教授,博导
浙江大学化学工程与生物工程学系生物工程研究所,杭州,邮编310027
E-mail   yuhongwei@zju.edu.cn
 
 
Prof. Yu Hongwei
Mailing address: Institute of Bioengineering, Department of  Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China, 310027.
Office: Room 6109, Building Jiao 10, YuQuan Campus, Zhejiang University
Contact information: Tel. (O): 86-0571-8795 1873
E-mail: yuhongwei@zju.edu.cn
   Professor Yu obtained his Bachelor degree in 1995 and Master degree in 1998 in Chemical Engineering from Tsinghua University, China and his Ph.D in 2002 in Chemical Engineering from National University of Singapore, Singapore,supervised by Prof. Ching Chi Bun. After working in National University of Singapore, Nanyang Technological University and California Institute of Technology, he went back China and took the professorship in Zhejiang University in 2007. Professor Yu had studied chiral drug separation technologies for many years, including chromatographic technologies (simulated moving bed) and enzymatic resolution of racemic mixture. His research interests are now focused on improving enzyme activity and enantioselectivity by genetic engineering to produce chiral compounds. In recent years, his research interests are expanded to biosynthesis of natural products by metabolic engineering.
Research Interests
1) Enzymatic Engineering;
2) Chiral Drug Separation;
3) Genetic Engineering, Enzyme Directed Evolution;
4) Metabolic Engineering
 
 
教育背景:
19991月— 20021: 在新加坡国立大学化学与环境工程系攻读博士学位,并于200210月获工学博士学位。
19959月—19987: 在清华大学核能技术研究院学习,获工学硕士学位。
19909月—19957: 在清华大学化学工程系学习,获工学学士学位。
 
工作经历:
19987月—199812月:清华紫光英力公司,研发工程师.
20022月— 20051月:新加坡国立大学化学及过程工程中心,博士后研究员
20052月—20076月:新加坡南洋理工大学化学与生物分子工程系,博士后研究员。其间20059月—20063月,在美国加州理工学院作访问学者, 进行酶的定向进化研究.
20077月—:浙江大学化学工程与生物工程学院,教授,博导
 
代表性文章:
1.    Xiaomei Lv, Fan Wang, Pingping Zhou, Lidan Ye, Wenping Xie, Haoming Xu & Hongwei Yu* Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae, Nature Communications,  2016,7.
2.       Wenping Xie, Xiaomei Lv, Lidan Ye, Pingping Zhou, Hongwei Yu* Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering, Metabolic Engineering, 2015, 30: 69-78.
3.       Wenqiang Lu, Lidan Ye, Xiaomei Lv, Wenping Xie, Jiali Gu, Zhaofeng Chen, Yongqiang Zhu, Aipeng Li, Hongwei Yu*, Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q10 production in Rhodobacter sphaeroides, Metabolic Engineering, 2015, 29: 208–216.
4.       Wenping Xie, Lidan Ye, Xiaomei Lv, Haoming Xu, Hongwei Yu * Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae, Metabolic Engineering, 2015,8: 8-18.
5.       Wenqiang Lu, Lidan Ye, Haoming Xu, Wenping Xie, Jiali Gu, Hongwei Yu * Enhanced production of coenzyme Q10 by self-regulating the engineered MEP pathway in Rhodobacter sphaeroides, Biotechnology and Bioengineering, 2014, 111: 761-769.
6.       Wenping Xie, Min Liu, Xiaomei Lv, Wenqiang Lu, Jiali Gu, Hongwei Yu *,Construction of a Controllable β-carotene Biosynthetic Pathway by Decentralized Assembly Strategy in Saccharomyces cerevisiae. Biotechnology and Bioengineering 2014, 111(1): 125-133.
7.       Fei Guo, Stefan Franzen, Lidan Ye, Jiali Gu, Hongwei Yu * Controlling Enantioselectivity of Esterase in Asymmetric Hydrolysis of Aryl Prochiral Diesters by Introducing Aromatic Interactions. Biotechnology and Bioengineering, 2014,111(9),1729-1739.
8.       Min Liu, Jiali Gu, Wenping Xie, Hongwei Yu *,Directed co-evolution of an endoglucanase and a β-glucosidase in Escherichia coli by a novel high-throughput screening method. Chemical Communications. 2013,49,7219-7221.
工作研究领域

研究领域: 酶固定化,酶定向进化及理性设计, 酶催化手性药物拆分及合成的研究;代谢工程

联系方式

电子信箱:yuhongwei@zju.edu.cn